ABSTRACT
Aim: of this study was to investigate the significance of apoptosis-related genes bcl-2 and Bax in breast carcinoma cases treated with radical surgery plus radiotherapy and adjuvant chemotherapy for at least 1 year and their relation with expression of p53
Methods: After surgical resection imunohistochemistry was performed to determine Bcl-2, Bax, p53 and estrogen receptor [ER] expression in paraffin-embedded tissues of 50 invasive breast cancers. And overall survival was assessed
Results: Bcl-2, Bax, P53 and ER immunostaining displayed a positive relation with increasing histologic grade [P=0.000] and negative relation with time staging. Bcl-2 displayed a negative relation with p53 [P=0.035] and a positive relation with Bax and ER [P= 0.003 and P= 0.011 respectively]. Expression of Bc12 was associated significant improvement in overall survival [P=0.01]
Conclusion: regulation of apoptosis is important in invasive ductal carcinoma. These results indicate that bcl-2 expression is significantly associated with hormonal receptor status so it is good prognostic marker, and that p53 is a significant prognostic marker. No significant relation between Bax and overall survival in relation to the stage, p53 or ER